He is an expert on the physiology of healthy human ageing and living proof that our later years can be lived well. We are all living longer. This stud... We characterised the adherent cell types isolated from human skeletal muscle by enzymatic digestion, and demonstrate that even at 72 hours post-isolation these cultures consist predominantly of myogenic cells (CD56(+), Desmin(+)) and fibroblasts (TE-7(+), Collagen VI(+), PDGFRα(+), Vimentin(+), Fibronectin(+)). Some of the twenty diseases of ageing Ageing Hypertension Type 2 Diabetes Coronary heart Disease Colon Cancer … Effect of glucose and hormones on adenylate cyclase, Return to normal of blood glucose, plasma-insulin, and weight gain in New Zealand obese (NZO) mice after implantation of streptozotocin treated islets of Langerhans, Return to normal of blood-glucose, plasma-insulin, and weight gain in New Zealand obese mice after implantation of islets of Langerhans RJ Gates, R Smith, MI Hunt, NR Lazarus - The Lancet, 1972 - Elsevier, Glucose-mediated insulin release from mouse islets of Langerhans: adenylate cyclase, Glucose-mediated insulin release from mouse islets of Langerhans: cyclic nucleotide phosphodiesterase, Insulin-resistant hyperglycemia produced by aminophylline, Circulating intermediate species of proinsulin and insulin in human subjects, Electrophoretic characterization of circulating human proinsulin and insulin, Biologically active circulating proinsulin-like materials from an islet cell carcinoma patient, Decreased Glucose Tolerance in the Rat Following Hypophysectomy, Circulating Proinsulin-like Material in Patients with Functioning Insulinomas, A method for electrophoretic characterization on polyacrylamide gel of circulating insulin immunoreactive substances, Synthesis and release of proinsulin and insulin by isolated rat islets of Langerhans. Regular and vigorous exercisers appear to be the logical choice for studying the inherent aging process as they are essentially free from the complications of disuse. The major hypothesis driving this research is that physical activity which is part of our evolutionary history is essential for health. Dr Norman Lazarus, 84, is an exception. At the same time, L-phenylalanine neither stimulated nor inhibited insulin release. When NZO mice were implanted with normal islets of Langerhans their blood glucose and plasma insulin declined. The cerebrospinal fluid (CSF) concentration of fructose is elevated in diabetes. Browse The TLS Shop for a big selection of Family & health books and the latest book reviews from The Times Liter Degradation was stimulated by the addition of glutathione and dithiothreitol. We assessed immune profiles in 125 ad... Sedentary time (ST) and moderate to vigorous physical activity (MVPA) are associated with cardiometabolic health. Glucose-initiated insulin release was as effective in the presence of beta-gamma-methylene ATP, a... Intraperitoneal injections of avian pancreatic polypeptide (APP) and bovine pancreatic polypeptide (BPP) are capable of returning to normal the hyperinsulinaemia, hyperglycaemia and weight gain of New Zealand obese mice. 544, $149.00, B-cell responses to IV glucose and glucagon in non-diabetic twins of patients with type 1 (insulin-dependent) diabetes mellitus, Events leading to insulin-dependent diabetes, N-terminal sequence analysis of human placental protein 14, purified in high yield from decidual cytosol, Characterization and quantification of copper sulfate-induced vascularization of the rabbit cornea, The role of phosphoenolpyruvate in insulin secretion: the effect of L-phenylalanine, The Internalisation of [ 125 I] Insulin by Isolated Rat Hepatocytes, 125I-labelled insulin degradation by isolated rat hepatocytes: The roles of glutathione-insulin transhydrogenase and insulin-specific protease, Immunological and kinetic properties of pyruvate kinase in rat pancreatic islets, A neuropeptide of the blowfly Calliphora vomitoria with amino acid composition homologous with vertebrate pancreatic polypeptide, Isolation and partial characterization of pancreatic polypeptide-like material in the brain of the blowfly Calliphora vomitoria, The metabolism of125I-labelled insulin by isolated Zucker rat hepatocytes, Hystricomorph Insulins and Insulin Receptors, A monomeric insulin from the porcupine (Hystrix cristata), an Old World hystricomorph, Degradation of 125 I-labelled insulin by isolated rat hepatocytes, The use of hystricomorph insulins in defining the insulin receptor interactions, Hystricomorph insulins and insulin receptors. The B-cells of patients with recently diagnosed Type 1 (insulin-dependent) diabetes may have no response to glucose when the response to glucagon is present but attenuated. Prior to King's College London, he was successively Head of Diabetes Research, Biochemical Research and Cell Biology for the Welcome Foundation. Something went wrong. ATP (5 muM) is abot to augment the Ca2+ effect. In his first audiobook, The Lazarus Strategy, Norman will inspire listeners to embrace the coming years with equal measures of optimism and determination; celebrating the good news of his research - that staying active is scientifically proven to keep the body young and healthy … Dr Lazarus has now written a remarkable book, with the aim of helping others to stay well for longer.The Lazarus Strategy is a part how-to and part manifesto on the art of healthy ageing to guide readers along the path to a more active, productive, independent future and a medication-free life. 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